![]() Keep in mind that both fresh and frozen juices have the same effect.Īccording to the Cleveland Clinic, there are instance when consuming moderate amounts of grapefruit appear to be safe. Others may need to consume more of the fruit or juice to have an interaction. Just one grapefruit or one glass of grapefruit juice could be enough to cause an interaction in some people. The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown. How much grapefruit is ok while on certain statins? If you use a skin patch or receive your medication through an injection, you may have a lower risk of adverse effects. This is because the interaction happens in your digestive tract. Interestingly, the interaction between grapefruit and medications poses a danger only when taken orally. Grapefruit doesn’t affect other statins because they are metabolized by a different enzyme, CYP2C9. This compound deactivates the CYP3A4 enzyme that the body uses to metabolize, or process, these particular statins. Furanocoumarins are organic chemical compounds present in many different plants, including grapefruit. The secret to the interaction between grapefruit and these statins is in furanocoumarins, according to a 2017 study. You only need to avoid grapefruit if your doctor prescribes lovastatin, atorvastatin, or simvastatin. For this reason, you might avoid the fruit altogether. One misconception is that you shouldn’t mix grapefruit with any statin drug. ![]() If you’re prescribed a statin, it’s important to understand which ones can interact negatively with grapefruit and grapefruit juice. Retrieved March 23, 2009.How grapefruit interacts with certain statins This claim has no support from a biochemical standpoint and cannot be substantiated. ![]() The Grapefruit Diet: Another name for this diet is the "10-day, 10-pounds- off diet." The premise of this diet is that grapefruit eaten before each meal acts as a "catalyst" to burn body fat and thereby causes hastened weight loss. ^ "Fellows Find: Fannie Hurst and Diets".Hollywood and the Rise of Physical Culture. Encyclopedia of Pseudoscience: From Alien Abductions to Zone Therapy. This diet will not be beneficial to anyone when followed long-term, as the extremely low calorie intake could lead to malnutrition and many health problems. While eating half a grapefruit with every meal may be a good way to incorporate more fruit in the diet of a healthy person, grapefruit and grapefruit juice is harmful if the dieter is allergic to citrus, or is taking medicines that can interact with grapefruit juice. The variations of the grapefruit diet that are too low in calories (below 800–1,000 calories a day), too low in carbohydrates, or too low in essential micronutrients are considered unhealthy and potentially dangerous. In 1936, Lewis Wolberg described the diet as "nonsensical, irrational and even dangerous". He noted that many people became ill on the diet and "casualties" were heavy around Hollywood. Carl Malmberg commented that it lacks in all the necessary minerals ( calcium, phosphorus and iron) and in vitamin A. The diet was criticized as early as 1935. The idea that grapefruit eaten before a meal acts as a "catalyst" to burn body fat has no evidence from biochemistry. It was re-popularized in the 1980s and nicknamed the "10-day, 10-pounds-off diet". Novelist Fannie Hurst was a notable devotee of the diet. The Mayo Clinic has disavowed the grapefruit diet. The diet then became a fad in Hollywood and spread throughout America. One rumour traces the diet to actress Ethel Barrymore, who is alleged to have paid William James Mayo and his brother 500 dollars (equivalent to $9,000 in 2022) to create a special diet for her. It was originally known in 1929 as the "eighteen-day diet", and featured 18 days of grapefruit, orange, toast, vegetable and egg combinations, totalling approximately 500 kilocalories (2,100 kJ). The grapefruit diet originated in the 1930s. The grapefruit diet lasts for 10 to 12 days followed by 2 days off. The grapefruit diet does not require exercise. The diet is based on the claim that grapefruit has a fat-burning enzyme or similar property. A typical breakfast menu usually includes bacon and eggs. The grapefruit diet is thus a low-carbohydrate diet. Sugar, fruits (other than grapefruit), sweet vegetables, grains and starchy vegetables are to be avoided. There are variations on the diet, although it generally consists of eating one grapefruit at each meal, along with meat, eggs, other foods that are rich in fat and protein, and certain vegetables. The Grapefruit diet (also known as the Hollywood diet and the 18-Day diet) is a short-term fad diet that has existed in the United States since at least the 1930s.
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